Pyle's film credits include Galaxy Quest, Dodgeball: A True Underdog Story, Tim Burton's Charlie and the Chocolate Factory and more recently Harold & Kumar: Escape from Guantanamo Bay. Her television credits include two episodes of Heroes as Vegas showgirl/criminal Hope, as well as episodes of Mad About You, Boston Legal, Two and a Half Men and The Sarah Silverman Program. In 2012 she was part of the main cast of Greetings from Home. As of 2016, she has a total of over 140 onscreen credits.
She also appeared in an unaired episode of The O.C. with fellow Daisies episode guest star Autumn Reeser.